This presentation will provide an in-depth overview of the Human Subjects Office’s new Clinical Trials Compliance Monitoring. Attendees will gain insight into the structured processes designed to safeguard participant safety, ensure data integrity, and uphold regulatory standards. Key topics will include the roles and responsibilities of research personnel, audit procedures, risk-based monitoring strategies, and the use of systems like OnCore, eReg, and EPIC for data verification. The session will also highlight how proactive monitoring can identify protocol deviations early, reduce rework, and support continuous improvement in clinical research practices.